The effect of angiogenesis induction on vertical bone augmentation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nihon University
• Principal Investigator: SATO Shuichi 日本大学, 歯学部, 教授 (50225942)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血管新生 / 骨再生 / 垂直方向 / ラット

Outline of Final Research Achievements

The purpose of these studies were investigated the effect of angiogenesis induction on vertical bone augmentation. First study showed basic fibroblast growth factor(FGF-2) promoted angiogenesis earlier on rat non-critical and critical bone defects.The second study evaluated angiogenesis and bone augmentation with rat calvarila guided bone agumentation (GBA) model using micro-CT.The results showed angiogenesis began at sites from brain arteries and gradually increased at bone marrow penetration to vertical direction. The bone augmentation enhanced angiogenesis in rat calvaria GBA model. The third study investigated effect of platelet-derived growth factor (PDGF) on rat calvarial GBA model. The results showed 0.03% PDGF in collagen sponge and chitosan sponge enhanced vertical bone formation on rat calvarium.

Free Research Field

再生治療