Development of the artificial bone having a living body resemblance trabecula structure with nanoapatite and the nanocollagen

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Yagami Kimitoshi 松本歯科大学, 歯学部附属病院, 准教授 (00210211)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Hiroshi 松本歯科大学, 歯学部, 講師 (00278178) ; MAKI Shigeru 松本歯科大学, 歯学部, 教授 (20134942) ; SADAOKA Sunao 松本歯科大学, 歯学部, 助教 (80549395) ; KAWAHARA Ichiroh 松本歯科大学, 歯学部, 講師 (20319114)
• Co-Investigator(Renkei-kenkyūsha): UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801) ; KUBOKI Yoshinori 北海道大学, 歯学部, 教授 (00014001)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨再生 / 糖尿病 / 骨粗鬆症 / ナノコラーゲン / βTCP / 人工骨 / VEGF / ドラッグデリバリー

Outline of Final Research Achievements

The purpose of development of the bone regeneration therapy for the aggravated alveoral bone resorption due to diabetes mellitus or the osteoporosis, we used nano-atelocollagen with diabetes mellitus / osteoporosis model animal in DDS-HB37H which had a geometry structure and culture attached the mesenchymal cells which gave target medicine and evaluated blood vessel growth in the bone formation and relations with the collagen.　As a result, DDS-HB37H made expression of VEGFmRNA reinforced with osterix and the ALP which were osteo- induction factor.　Also, VEGF expression increased in bone formation region, and blood vessel was formed in richness.　Therefore, DDS-HB37H is thought effective bone regeneration material for diabetes mellitus and the osteoporotic patients.

Free Research Field

医歯薬学