Study for influences of activities of sympathetic nerve for pain, differentiation, function and innervation of the mastocatory muscles

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SATO Jun 北海道大学, 歯学研究科(研究院), 講師 (60319069)
• Co-Investigator(Kenkyū-buntansha): KITAGAWA Yoshimasa 北海道大学, 歯学研究科(研究院), 教授 (00224957) ; YAMAZAKI Yutaka 北海道大学, 歯学研究科(研究院), 教授 (90250464)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 咀嚼筋 / 交感神経 / 副交感神経 / 口腔顎顔面痛 / 慢性疼痛 / ウサギ

Outline of Final Research Achievements

The number of the patients with refractory and chronic orofacial pain is increasing. Many sources of the pain are originated from muscle pain. Muscle pain gets worse by excessive physical and mental stresses. The aim of this study is to elucidate the relationships between pain of the masticatory muscles and activities of sympathetic nerve using some clinical and experimental studies. Clinical studies indicated that inhibition of the activity of sympathetic nerve by irradiation with soft laser to cervical region may cause the changes of threshold of muscle pain. The degree of the change was more prominent in patients with muscle pain than the healthy controls. Experimental studies using growing rabbits indicated that enzyme histochemical adaptive responses and morphological changes of the masseter masticatory muscles after sympathectomy of superior cervical ganglion were observed.

Free Research Field

口腔外科学、口腔内科学一般