Pathological condition elucidation of bisphosphonate-related osteonecrosis of the jaw which applied mechanical stress

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Akita University
• Principal Investigator: Takano Hiroshi 秋田大学, 医学部, 助教 (30282172)
• Co-Investigator(Kenkyū-buntansha): FUKUDA MASAYUKI 秋田大学, 医学部, 准教授 (20272049)
• Co-Investigator(Renkei-kenkyūsha): NAKATA AKIRA 秋田大学, 医学部, 助教 (50400510)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ビスフォスフォネート製剤関連顎骨壊死 / ビスフォスフォネート製剤 / 骨芽細胞 / メカニカルストレス

Outline of Final Research Achievements

In this study, we clarified that bisphosphonate（BP) raised ALP activity and suppressed expression and production of OPG on osteoblasts, in addition, mechanical compression stress also suppressed expression and production of OPG. Therefore, BP promotes osteoblasts differentiation by a rise of ALP, but it is thought that promote osteoclasts differentiation by fall of OPG. Accordingly, as for BP and the mechanical compression stress to jawbone, what deposition to alveolar bone of BP and jawbone promoted because we were accelerated and acted on bone metabolic turnover in osteoblasts was suggested. When they elucidate one end of a clinical condition formation mechanism of BRONJ, this study results give fundamental knowledge.

Free Research Field

外科系歯学