Studies on the molecular mechanism of hyposalivation after irradiation, focusing on aquaporin-5, for clinical applications

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Gunma University
• Principal Investigator: SUSA Taketo 群馬大学, 医学(系)研究科(研究院), 研究員 (10622558)
• Co-Investigator(Kenkyū-buntansha): YOKOO Satoshi 群馬大学, 医学系研究科, 教授 (00322206) ; MATSUZAKI Toshiyuki 群馬大学, 医学系研究科, 教授 (30334113)
• Research Collaborator: TANIGUCHI Akie
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線照射 / 唾液腺 / アクアポリン

Outline of Final Research Achievements

We analyzed the relationships between the hyposalivation after irradiation to head and neck region and the expression and subcellular distribution of water channel aquaporin-5 that plays an important role in water secretion in the salivary gland acinar cells using rats and mice. Single dose irradiation of 15 gray to these animals caused apparent reduction of saliva in 1 month and the reduction continued until 2 months. No apparent change in either the expression or subcellular distribution of aquaporin-5 was found in the parotid glands, although there were some abnormal cells having larger nuclei. Pretreatment with pilocarpine did not show apparent protective effect against hyposalivation in our current study.

Free Research Field

口腔外科学