2016 Fiscal Year Final Research Report
Study on sphingosine-1-phosphate signaling pathways in multistage carcinogenesis of the oral cancer
| Project/Area Number |
25463069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Takahiro Abe 東京大学, 医学部附属病院, 特任講師 (20383250)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 口腔癌 / S1P |
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is a metabolized product of the sphingolipid. It acts as an important factor in regulating malignant tumor progression, arteriosclerosis, diabetes, osteoporosis, etc. Therefore, it has attracted a lot of attention in the recent times. S1P is secreted by various cells and acts in an autocrine or paracrine manner as a signaling factor through five specific G protein-coupled receptors, but S1P signal transduction in oral cancer is still not clear. In this study, we examined the influence of S1P on cell proliferation and cell migration by using cell lines of oral squamous cell carcinoma. We obtained some knowledge about S1P-signaling only after confirmation with an expression pattern of the S1P receptor subtype (S1PR1-5) of the cell lines.
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| Free Research Field |
口腔外科学
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