Creation of a rat model of the periodontal disease, and research of the bone regeneration treatment using the osteogenic small chemical compound

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463070
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Hatano Noriko 東京大学, 医学部附属病院, 登録診療員 (70396737)
• Co-Investigator(Kenkyū-buntansha): ABE Masanobu 東京大学, 保健・健康推進本部, 講師 (10392333) ; SETO Ichiro 東京大学, 医学部附属病院, 講師 (30582390) ; YAMAMOTO Kenichi 東京大学, 工学(系)研究科(研究院), 特任研究員 (90583162)
• Co-Investigator(Renkei-kenkyūsha): TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454) ; CHUNG Ung-il (TEI Yuichi) 東京大学, 工学(系)研究科(研究院), 教授 (30345053) ; OHBA Shinsuke 東京大学, 工学(系)研究科(研究院), 准教授 (20466733)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨再生

Outline of Final Research Achievements

In this study, it was aimed for the alveolar bone regeneration with the osteogenic small chemical compound to regenerate of the irreversible bone defect part by periodontitis. Osteogenic helioxanthin-derivative (TH) incorporated the solution which let（2-Hydroxypropyl)-β-cyclodextrin(CD) include it into cellulose was made the gel. The gel had osteoblastic differentiation inducibility, and there was not the cytotoxicity. We made the rat model of periodontal disease that was near the natural development of the symptoms of periodontitis. After giving TH-containing gel using the rat model in the place where the defect of alveolar bone, predominance had few alveolar bone losses. There are not the cytotoxicity in vivo.

Free Research Field

口腔外科