Clarification of risk factors for progressive condylar resorption and development of prevention method with intermittent PTH(1-34) treatment

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: Kobayashi Tadaharu 新潟大学, 医歯学系, 教授 (80195792)
• Co-Investigator(Kenkyū-buntansha): FUNAYAMA AKINORI 新潟大学, 医歯学系, 助教 (80529686) ; KOJIMA TAKU 新潟大学, 医歯学系, 助教 (90515777) ; MIKAMI TOSHIHIKO 新潟大学, 医歯学総合病院, 特任助教 (90595745)
• Co-Investigator(Renkei-kenkyūsha): INOUE KAYOKO 新潟大学, 医歯学系, 特任准教授 (90303130)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: PCR / 骨強度 / 骨粗鬆症ラット / 骨代謝マーカー / 顎変形症

Outline of Final Research Achievements

Progressive condylar resorption (PCR) following orthognathic surgery is characterized by reduction of condylar volume and decrease of ramus height. However, etiology of PCR remains unclear.
In our experimental study with rat mandibular distraction model, morphological findings after distraction indicated deformation of the condyle, especially in the rats receiving Tacrolimus. The findings suggest that overloading to the condyle and decrease of bone strength are key factors for PCR.
In our clinical study using patients with jaw deformities, bone formation and resorption markers tended to be higher in patients with a protrusive mandible. On the other hand, patients with mandibular retrusion had a higher tendency to have small and dense condylar processes. The results suggest that growth depression or a degenerative change in the mandibular condyle is involved in the pathogenesis of mandibular retrusion, although risk factors for progressive condylar resorption were not determined.

Free Research Field

外科系歯学