2015 Fiscal Year Final Research Report
The analysis of micro RNA in 4NQO-induced rat tongue cancer model
| Project/Area Number |
25463075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKITA HIROKI 岐阜大学, 大学院医学系研究科, 講師 (50345790)
SHIBATA TOSHIYUKI 岐阜大学, 大学院医学系研究科, 教授 (50226172)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | miRNA / 4NQO舌癌ラットモデル |
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| Outline of Final Research Achievements |
We aim to examine the usefulness of 4-NQO induced rat tongue cancer as human oral carcinogenesis model by analyzing miRNA's which expression abnormality is reported in in human squamous cell carcinoma.
We identified upregulation of mir21 and downregulation of miR-99a and miR-100 like human squamous cell carcinoma in this study,but it was not the significant difference.On the other hand,the expression of miR155 and miR130b was downregulation unlike human squamous cell carcinoma.
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| Free Research Field |
口腔癌
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