Feasibility of Molecularly Targeted Therapy for Tooth Regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyoto University
• Principal Investigator: Takahashi Katsu 京都大学, 医学(系)研究科(研究院), 准教授 (90314202)
• Co-Investigator(Kenkyū-buntansha): BESSHO Kazuhisa 京都大学, 大学院医学研究科, 教授 (90229138) ; SHIMIZU Akira 京都大学, 大学院医学研究科, 教授 (00162694) ; SUGAI MANABU 福井大学, 大学院医学研究科, 教授 (90303891)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯の再生 / 歯数制御 / 分子標的治療 / USAG-1 / Runx2 / CEBP/β

Outline of Final Research Achievements

Human teeth are diphyodont excepting the permanent molars. The number of teeth is usually strictly determined. A number of mouse mutants provide insights into the supernumerary tooth formation. The rescue of tooth formation in genetically defined mouse models clearly demonstrates the feasibility of inducing de novo tooth formation via the in situ repression of a single targeted gene. Our investigations and related studies clearly validate the hypothesis that the de novo repression of target genes could be used to stimulate arrested tooth germs in order to induce new tooth formation in mammals. Molecular targeted therapy is a type of treatment in which drugs or other substances are used to specifically attack certain cell types by interfering with critical target molecules.
Molecularly targeted therapy seems to be a suitable approach in tooth regeneration.

Free Research Field

口腔外科