• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Development and sensory inputs in neural network for sucking

Research Project

  • PDF
Project/Area Number 25463083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

ISHIHAMA KOHJI  大阪大学, 歯学研究科, 招へい教員 (30432454)

Project Period (FY) 2013-04-01 – 2017-03-31
KeywordsNMDA受容体 / 三叉神経
Outline of Final Research Achievements

Chemical synapses contain a number of diverse proteins, which form the postsynaptic density (PSD), and these are involved in synaptic structure, neurotransmission and signal transduction. PSD-95 is implicated in the formation and maturation of excitatory synapses. PSD-95 regulates the localization of NMDA receptors by means of binding with NMDA receptor subunit 2 (NR2). Rhythmical oro-maxillofacial activities, such as suckling and chewing, are generated in the brainstem, and we showed that NMDA receptors play a critical role in the rhythm and pattern generation and signal transmission around the trigeminal motor nucleus during prenatal and early postnatal development. Here, we immunohistochemically examined the temporal distribution of PSD-95 protein in developing rat brainstem from suckling to the mature chewing stage. There was early emergence of PSD-95 expression in the interneurons located in the medial region of the trigeminal motor nucleus.

Free Research Field

口腔外科学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi