2015 Fiscal Year Final Research Report
Function analysis of TMEM16E using TMEM16E knockout mice
| Project/Area Number |
25463085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
MIZUTA KUNIKO 広島大学, 医歯薬保健学研究院(歯), 助教 (40432679)
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| Co-Investigator(Kenkyū-buntansha) |
TOBIUME KEI 広島大学, 大学院医歯薬保健学研究院(歯), 准教授 (40350037)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | TMEM16E / ノックアウトマウス / 筋ジストロフィー / GDD |
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| Outline of Final Research Achievements |
In this study, TMEM16E knockout mice showed no phenotypic signs. The result suggested that the function of TMEM16E was compensated by other muscular dystrophy related molecules. During in vitro human myogenic cell differentiation, TMEM16E protein expression was up-regulated in mitotic myoblasts as well as myotubes. This finding suggests that TMEM16E protein expression is regulated in a cell cycle dependent manner.
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| Free Research Field |
外科系歯学
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