2015 Fiscal Year Final Research Report
Regeneration of hypofunctional salivary gland with the stem-like cell
| Project/Area Number |
25463092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Fukuoka Dental College (2015)
Kumamoto University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA MASANORI 熊本大学, 医学部附属病院, その他 (90117127)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 唾液腺 / 再生 / 放射線 |
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| Outline of Final Research Achievements |
We observed submandibular gland of irradiated mouse decreased α-amylase, EGF, EGFR, HGF, c-Met, bFGF and FGFR. The stem-like cell of mouse submandibular gland showed similar findings to them with exposure to radiation. From the results of these experiments, we induced regeneration of the stem-like cell suffered from radiation damage and demonstrated EGF, KGF and type IV collagen play an important role in function recovery.
To clear its mechanism, we require further research.
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| Free Research Field |
外科系歯学
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