The development of the specific molecular target drug for oral cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: ONDA Takeshi 東京歯科大学, 歯学部, 講師 (30433949)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔扁平上皮癌 / 分子標的治療 / バイオマーカー / トランスクリプトーム / プロテオミクス / メタボロミクス / HSP90 / PDE5

Outline of Final Research Achievements

Recently, molecular targeted drugs have begun to emerge. They have recently been in use for clinical standard treatment and reportedly have a high therapeutic effect. However, molecular targeted therapy has neither been established for oral squamous cell carcinoma nor has been defined effective target molecules. A research representative has listed 167 target molecule candidates for oral squamous cell carcinoma by getting Omics analysis technology into full use. The present study intended to examine the serviceability and applicability of listed up abnormal molecule expression as a tumor marker and attempt the feasibility of developing into clinical tests after conducting pre-clinical test using animal models. The result of this study revealed that HSP90 and PDE5 have potentials to become good candidates as therapeutic targets for oral squamous cell carcinoma.

Free Research Field

口腔外科学