2015 Fiscal Year Final Research Report
Development of a new oral cancer treatment via regulation of the anti-tumor factor BRAK expression with DNA methylation inhibitors.
| Project/Area Number |
25463101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
MAEHATA YOJIRO 神奈川歯科大学, 歯学研究科(研究院), 講師 (80410009)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口腔癌 / CXCL14/BRAK |
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| Outline of Final Research Achievements |
In this study, we examined the effect of anti-tumor activity via upregulation of CXCL14/BRAK expression by treatment of the epigallocatechin gallate (EGCG) in oral squamous cell carcinoma (HNSCC). As a result, EGCG did not showed significantly increased of the expression of BRAK.Therefore, we examined the effects of DAC on expression of BRAK by using a potent methylation inhibitor decitabine. As a result, we confirmed the inhibitory effect of tumor growth via upregulation of BRAK in vivo. These data indicate that it is very useful in oral cancer treatment strategy by using the methylation inhibitors or natural products with a methylation inhibitory effect.
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| Free Research Field |
歯科薬理学
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