Possible application of 405-nm blue light irradiation for the treatment and the prevention of oral candidiasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463102
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University
• Principal Investigator: YAMACHIKA Shigeo 鶴見大学, 歯学部, 講師 (60182565)
• Co-Investigator(Kenkyū-buntansha): SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715) ; TATEHARA Seiko 鶴見大学, 歯学部, 講師 (90380089) ; TOKUYAMA Reiko 鶴見大学, 歯学部, 助教 (20380090) ; IDE Shinji 鶴見大学, 歯学部, 助教 (00611998)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔カンジダ症 / 光線力学療法 / 405nmレーザー光

Outline of Final Research Achievements

Although oral candidiasis, an opportunistic infection caused by Candida species, has been conventionally treated by topical and/or systemic administration of antifungal agents, this mediation therapy is prone to raise the drug resistance of Candida species as well as multiple side effects. Therefore, it is important to establish a minimally invasive therapeutic strategy and prophylactic approach for oral candidiasis. Here, we focused on photodynamic therapy with 405-nm blue light, and examined the effect of 405-nm blue light irradiation on the growth of Candida albicans (C. albicans).
Results: Irradiations at 200 mW of the output for 10 and 20 minuets showed about 55 % and 90 % significant growth inhibition, respectively. C. albicans growth was suppressed by 405-nm blue light irradiation, suggesting that 405-nm blue light irradiation is a promising means for treatment and prevention of oral candidiasis.

Free Research Field

口腔外科