2015 Fiscal Year Final Research Report
The roles of catecolaminergic neuron in relationships Diffuse Noxiou Inhibitory Controls and chronic pain
| Project/Area Number |
25463128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University (2014-2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 広範囲侵害性抑制性調節 / 下行性抑制系 |
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| Outline of Final Research Achievements |
Diffuse Noxious Inhibitory Controls (DNIC) or Conditioned Pain Modulation (CPM) is a phenomenon that the effects of a noxious stimuli in inhibited by heterotopic noxious stimuli. Descending inhibitory controls, including catecholamine neuron system, are not well investigated. Systemic administration of Phenylephrine (PE α1-adrenoceptor agonist) is found to inhibit diffuse noxious inhibitory control (DNIC) in rats. The further study was designed to investigate the effect of intravenous administration of PE on CPM in humans.The study shows that systemic administration of an α1-adrenoceptor agonist (PE), the lower clinical dose, inhibited CPM in humans. These results may provide some mechanistic insight into why many chronic pain patients show impaired CPM. On the basis of the results, The next study shows that temporomandibular disorders (TMD) patients with temporomandibular joint (TMJ) pain had different conditioned pain modulation (CPM) compared with healthy subjects.
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| Free Research Field |
歯科麻酔学分野
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