2015 Fiscal Year Final Research Report
Circulatory dynamics after administration of dexmedetomidine in antipsychotic rats
| Project/Area Number |
25463155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Tutui Yukako 日本歯科大学, 歯科麻酔学講座, 講師 (20434144)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | デクスメデトミジン / クロルプロマジン / アドレナリン反転 / P-Vカテーテル / 歯科用局所麻酔薬 |
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| Outline of Final Research Achievements |
Concomitant administration of chlorpromazine and adrenaline caused decreases in blood pressure. Vasoconstrictor dexmedetomidine (DEX) has a possibility for local anesthetics adjunct alternative as adrenaline. We measured circulatory dynamics of chlorpromazine rat after DEX injection.Blood pressure, end-diastolic volume, and end-systolic pressure increased. Stroke volume,stroke work, and pulse rate decreased. End-systolic elastance was no change.These results suggest that vasoconstriction effect of DEX increased preload and afterload. And DEX does not affect to cardiac function.
DEX has possibility to become safe anesthetic adjuncts for patients taking chlorpromazine.
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| Free Research Field |
歯科麻酔学
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