2016 Fiscal Year Final Research Report
Induction of neural stem cells and possible contribution to neurogenesis following transient brain ischemia
Project/Area Number |
25463159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Osaka Dental University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MAEDA Mitsuyo 理化学研究所, CLST-JEOL連携センターマルチモダル微細構造解析ユニット, 客員主管研究員 (40122080)
MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529)
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Research Collaborator |
NAKATA Masayo
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | 神経幹細胞 / ペリサイト / 一過性脳虚血 / 再灌流傷害 |
Outline of Final Research Achievements |
Using a mouse model of transient ischemia/reperfusion injury, we investigated the threshold of ischemic periods. In addition, we examined the origin of injury-induced neural stem cells: iNSCs and their possible contribution to neurogenesis under such pathologic conditions. Although iNSCs were induced following not only lethal ischemic injury by more than 30-min ischemia but also non-lethal ischemic injury by 15-min ischemia, the numbers of iNSCs were fewer under 15-min ischemic conditions compared with those observed under 30-min ischemic conditions. We also found that iNSCs are likely derived from brain pericytes stimulated by ischemic insult and that they had an activity of producing neuronal cells.
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Free Research Field |
歯科麻酔学
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