2015 Fiscal Year Final Research Report
Development of preventive method for BRONJ with acetylsalicylic acid
| Project/Area Number |
25463161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKUIRI Takashi 北海道大学, 大学院歯学研究科, 助教 (10322819)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 歯学 / ビスホスホネート |
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| Outline of Final Research Achievements |
Bisphosphonates-related osteonecrosis of the jaw (BRONJ) is the intractable disease that is osteonecrosis of the jaw in a patient who was receiving or had been exposed to bisphosphonate therapy. However, the mechanisms of BRONJ are not fully understood, and appropriate therapies have yet to be established. The aim of this study was the effect of acetylsalicylic acid (aspirin) on BRONJ. By the analysis of the BRONJ model mouse, an inflammatory reaction was reduced with acetylsalicylic acid. It was suggested that acetylsalicylic acid might reduce a BRONJ symptom.
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| Free Research Field |
矯正・小児系歯学
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