GPCR transcriptional map creation using NGS and bone regenerative medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ippei Watari 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10431941)
• Co-Investigator(Kenkyū-buntansha): INOUE K. A. (PODYMA K.A.) 東京医科歯科大学, 医歯学総合研究科, 助教 (90302877)
• Co-Investigator(Renkei-kenkyūsha): SHINOMURA Tamayuki 東京医科歯科大学, 医歯学総合研究科, 准教授 (70206118)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: GPCR / RNA seq / 次世代シークエンサー / 骨再生 / インクレチン / 唾液腺 / バイオインフォマティクス / 核酸医療

Outline of Final Research Achievements

In our study we have focused on G protein-coupled receptors in respect to their functions related to bone metabolism. We have revealed that incretin receptors belonging to the GPCR class B (GLP-1 receptor and GIP receptor) are expressed in osteoblastic cell line, MC3T3-E1, rat salivary glands and taste buds. The studies related to their exact function of incretin receptors in oral region are ongoing, at present we are implementing the comprehensive analysis of the transcription factors related to the incretin signals.

Free Research Field

歯科矯正学