Low-intensity pulsed ultrasound stimulation for mandibular condyle osteoarthritis lesions

2016 Fiscal Year Final Research Report

• Project/Area Number: 25463171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YONEMITSU Ikuo 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00431940)
• Research Collaborator: KANAGUCHI Akemi ; TAKEI Maki ; IKEDA Yuhei ; MIYAZAKI Mutsumi
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 顎関節 / 変形性関節症

Outline of Final Research Achievements

This study evaluated LIPUS effects in a rat TMJ-OA model. OA-like lesions were induced in the TMJ with low-dose MIA injections. Twenty-four 12-week-old male Wistar rats were divided into 4 groups: control, injected with contrast media at 12 weeks and observed to 20 weeks; LIPUS, injected with contrast media at 12 weeks and LIPUS performed from 16 to 20 weeks; MIA, injected with MIA at 12 weeks and observed to 20 weeks; and MIA+LIPUS, injected with MIA at 12 weeks and LIPUS performed from 16 to 20 weeks. BMD, BMC and BV were evaluated weekly with micro-CT. At 20 weeks of age, MIA+LIPUS group had significantly higher values than the MIA group did. The comparison of weekly results showed the MIA+LIPUS group showed a significant increase in BMD, BMC, and BV from 16 to 18 weeks.
LIPUS had significant therapeutic potential for treating TMJ-OA lesions in a 2-week period and it has non-invasive effects on the healthy mandibular condyle.

Free Research Field

顎関節の組織学的研究