Establishment of evidence of effectiveness of amoxicillin in the subjects at risk for infective endocarditis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: NEMOTO Hirotoshi 大阪大学, 歯学研究科, 招へい教員 (80527226)
• Co-Investigator(Kenkyū-buntansha): NAKANO Michiyo 岡山大学, 医歯(薬)学総合研究科, 教授 (30359848)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感染性心内膜炎 / アモキシシリン / 唾液 / 抗生物質 / 耐性菌 / 母子伝播 / 心疾患 / 術前投与

Outline of Final Research Achievements

Analyses of saliva specimens collected from healthy mothers and their children revealed that the prevalence rate of amoxicillin-resistant oral streptococci was approximately 5%, while that of clindamycin-resistant oral streptococci was approximately 30%. Other findings revealed resistance to other antibiotics by these strains as well as their possible transmission from mother to child. Thereafter, analyses of obtained oral specimens were performed to investigate the presence of amoxicillin-resistant strains in subjects at risk for infective endocarditis. However, we were unable to collect an adequate number of samples in order to analyze with statistical significance and consider that a large-scale study is necessary to perform this research.

Free Research Field

小児歯科学