2016 Fiscal Year Final Research Report
Investigation of mechanizm in orthodontocally root resorption through nothch signalinhg in periodontal ligament cells and Th17cells
| Project/Area Number |
25463200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 矯正歯科 / 歯根膜細胞 / 歯根吸収 / IL-17 / Notch シグナル |
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| Outline of Final Research Achievements |
Weinvestigated the Notch and IL -17 expressions in odontoclasts in resorbed roots during experimental tooth movement in vivo.8-week old male Wistar rats were divided into four groups, a heavy force group (50 g), optimal force group (10 g), jiggling force group (compression and tension, repetition; 10g) and a control group. The expression levels ofJagged1,Notch-2, RANKL, IL-6, IL -17 protein in the dental root determined using an immunohistochemical analysis.The immunoreactivity for Jagged1,Notch-2, RANKL, IL-6, IL -17in resorbed roots exposed to the jiggling force were stronger than that in the other groups on day 21. The number of IL-17-positive odontoclasts was significantly increased in the JF group on day 21 compared with the other groups.These results suggest that Jagged1,Notch-2, RANKL, IL-6, IL -17produced from periodontal tissues response to heavy and jiggling forces may induce odontoclastogenesis during orthodontic tooth movement, and may be one of risk factors for ORR.
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| Free Research Field |
歯科矯正学
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