2015 Fiscal Year Final Research Report
Role of IL-17A and IL-17F in periodontal inflammation.
| Project/Area Number |
25463213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Kobayashi Hiroaki 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (50396967)
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| Co-Investigator(Kenkyū-buntansha) |
NANBARA hiromi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (00632168)
ODA shigeru 東京医科歯科大学, 歯学部附属病院, 准教授 (70160869)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | IL-17 / 侵襲性歯周炎 |
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| Outline of Final Research Achievements |
Concentrations of IL-17A and IL-17F in serum have correlation with bone resorption in periodontits patients. After IL-17A and IL-17F stimulation, mRNA of CACL2, IL-8, b-defencin are unregulated in human epithelium cells. In co-stimulation with LPS, increased IL-8 and b-defencin mRNA are detected.
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| Free Research Field |
歯周病学
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