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2015 Fiscal Year Final Research Report

The role of IL-10 in the pathogenesis of chronic inflammatory periodontal disease

Research Project

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Project/Area Number 25463216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionNiigata University

Principal Investigator

Nakajima Takako  新潟大学, 医歯学系, 講師 (40303143)

Co-Investigator(Kenkyū-buntansha) TABETA Koichi  新潟大学, 医歯学系, 助教 (20401763)
ITO Harue  新潟大学, 医歯学系, 助教 (30397145)
Research Collaborator YAMAZAKI Kazuhisa  
YAMADA Hitomi  
MATSUDA Yumi  
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords歯周炎 / IL-10 / マウス / 抗炎症
Outline of Final Research Achievements

The effect of anti-inflammatory cytokine, IL-10, on inhibition of periodontitis was analyzed. Higher level of IL-10 gene expression was observed in human periodontitis tissues compare to gingivitis tissues. Ligature-induced periodontitis mice model demonstrated both gingival inflammation and bone resorption. Intraperitoneal injection of IL-10 but not direct injection of IL-10 into gingiva protected alveolar bone resorption in this mice model. However systemic IL-10 had no effect on inflammatory cytokine level in gingival tissues. Not only periodontal inflammation but also systemic responses may control periodontal bone resorption.

Free Research Field

歯周病学

URL: 

Published: 2017-05-10  

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