2016 Fiscal Year Final Research Report
Basic research for analysis of occlusal trauma mechanism using in vitro osteoclastogenesis assay
| Project/Area Number |
25463220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Nagasaki University |
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Principal Investigator |
UKAI Takashi 長崎大学, 病院(歯学系), 講師 (20295091)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 咬合性外傷 / 破骨細胞 / TNFα / RANKL |
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| Outline of Final Research Achievements |
RANKL pre-stimulation before stimulation of TNFa can induce active osteoclast formation. We showed the condition of RANKL pre-stimulation for forming of active osteoclasts. In this condition, osteoclast precursors expressed TRAF6. Moreover, blocking of TRAF6 at RANKL pre-stimulation inhibited TNFa inducing active osteoclast formation.
These results suggest RANKL pre-stimulation that TRAF6 is activated is important for forming of TNFa inducing active osteoclasts.
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| Free Research Field |
歯周病学
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