2015 Fiscal Year Final Research Report
Investigation of the molecular mechanisms involved in host cell invasion by periodontal pathogens under the exposure by cigarette smoke.
Project/Area Number |
25463228
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
|
Research Institution | Tokyo Dental College |
Principal Investigator |
Saito Atsushi 東京歯科大学, 歯学部, 教授 (60266559)
|
Co-Investigator(Kenkyū-buntansha) |
ISHIHARA KAZUYUKI 東京歯科大学, 歯学部, 教授 (00212910)
KOKUBU EITOYO 東京歯科大学, 歯学部, 助教 (70453785)
TAKAYAMA SAORI 東京歯科大学, 歯学部, 助教 (00550013)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 歯肉上皮細胞 / 喫煙 / タバコ煙 / Porphyromonas gingivalis / 歯周病原細菌 / 細胞侵入 / 細胞骨格 / 創傷治癒 |
Outline of Final Research Achievements |
Epithelial cells are recognized as the first line of defense against bacterial infection and environmental harmful stimuli such as cigarette smoke (CS). Currently, mechanisms by which CS affects cellular functions remain uncertain. We therefore investigated the effects of CS condensate (CSC) on in vitro wound closure of human gingival epithelial cells and their potential interactions with a major periodontal pathogen, Porphyromonas gingivalis. Low concentrations of CSC increased invasion of human gingival epithelial cells by P. gingivalis and induced changes in cytoskeleton and integrin expression, thereby modulating the cell migration.
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Free Research Field |
医歯薬学
|