2015 Fiscal Year Final Research Report
A bacterial non-coding RNAs search and the dynamics in serious periodontal disease
| Project/Area Number |
25463230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 遺伝子 / 細菌 / RNA / ncRNA / 遺伝子発現 / 歯周病 |
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| Outline of Final Research Achievements |
In this study, non-coding RNAs in P. gingivalis, T. forsythia, T. denticola related to severe periodontitis and in A. actinomycetemcomitans related to aggressive periodontitis were analyzed and identified comprehensively using a next generation sequencer. As a result, approximately 50-60% of ncRNA in various bacterial ncRNAs predicted in silico had their expressions actually. Also, new ncRNAs were discovered. This study is useful for the elucidation of new transcriptional regulations in pathogenic bacterial genes and for the diagnosis marker in a periodontal disease in the future.
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| Free Research Field |
生化学・分子生物学
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