2015 Fiscal Year Final Research Report
A study on the mechanism of alveolar bone metabolism focusing on Toll-like receptor and chemokines
| Project/Area Number |
25463232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEYAMA YOSHIAKI 北海道大学, 大学院歯学研究科, 准教授 (80271667)
KANEHIRA TAKASHI 北海道大学, 北海道大学病院, 講師 (90194935)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Toll様受容体5 / フラジェリン / ケモカイン / 歯槽骨 / 骨芽細胞 / TNF-alpha / IL-1beta |
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| Outline of Final Research Achievements |
Flagellin, the ligand of toll like receptor 5, induced expression of CX3CL1 mRNA, CXCL12 mRNA, in a dose-dependent manner on osteoblastic MC3T3-E1(E1) cells. In addition, the combination of flagellin and inflammatory cytokine such as TNF-alpha and IL-1beta, markedly increased gene expression of these chemokines on E1 cells. These results indicate that osteoblasts are one of the main cells which produce these chemokines and may play roles in host defense as well as bone metabolism.
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| Free Research Field |
予防歯科学
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