Effect of oral treatent during pregnancy of normal fetal growth

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: Takeuchi Noriko 岡山大学, 医歯(薬)学総合研究科, 助教 (50403473)
• Co-Investigator(Kenkyū-buntansha): MORITA Manabu 岡山大学, 大学院医歯薬学総合研究科, 教授 (40157904) ; EKUNI Daisuke 岡山大学, 病院, 講師 (70346443) ; TOMOFUJI Takaaki 岡山大学, 大学院医歯薬学総合研究科, 准教授 (80335629)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胎児発育 / 歯周疾患 / 酸化ストレス

Outline of Final Research Achievements

The aim of this study was to evaluate the effects of maternal periodontal disease on fetal growth through influence of oxidative stress.
Sample of 17 pregnant women was selected between April 2014 and January 2016. Periodontal examination was performed at the first, second and third trimester. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) level, an oxidative stress maker, had also been measured. Biparietal diameter, Femur lengh, and abdominal dircumference were corrected by ultrasonography and estimated fetal weight.
The estimate fetal weight of the high-PPD group at second trimester remained at a high level in comparison with the low-PPD group. However, there was no difference between two groups for urinary oxidative stress. The estimate fetal weight of the high-PPD group at third trimester remained at a high level in comparison with the low-PPD group. However, there was no difference between two groups for urinary oxidative stress.

Free Research Field

予防歯科