Production of novel rare sugar gum and study effects on resident bacteria in oral cavity with rare sugar gums

2016 Fiscal Year Final Research Report

• Project/Area Number: 25463248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Kagawa University
• Principal Investigator: OGAWA TAKAAKI 香川大学, 医学部附属病院, 助教 (50325338)
• Co-Investigator(Renkei-kenkyūsha): IZUMORI Ken 香川大学, 農学部, 名誉教授 (80035998)
• Research Collaborator: SAWADA Daijyou 香川大学, 医学部医学科, 大学院生 ; TADA Jyunko 香川大学, 医学部医学科, 大学院生 ; KHALEQUE Hasibul 香川大学, 医学部医学科, 大学院生
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: Ｄ-タガトース / キシリトール / Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｍｕｔａｎｓ / 口腔内細菌 / ガム

Outline of Final Research Achievements

D-tagatose is the most suitable for selecting rare sugars that are readily soluble in water, sugars with a degree of sweetness of 60% or more, and the effect for resident bacteria in the oral cavity. In vitro, when D-tagatose was added to the culture broth, proliferation against S. mutans such as GS5, acid and insoluble glucan production was markedly inhibited, biofilm formation was inhibited, and glucosyltransferase activity was inhibited. The production of D-tagatose gum was succeeded, and in vivo, used for 4 weeks of clinical trial. No side effects were observed in the subject. No. of oral bacteria, in particuler No. of S. mutans were decreased with the gums. This result was consistent with in vitro results.

Free Research Field

歯科口腔外科