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2015 Fiscal Year Final Research Report

The salivary gland culture system for developing the care of xerostomia.

Research Project

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Project/Area Number 25463286
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionYamagata University

Principal Investigator

SEKIMATA Akiko  山形大学, 医学部, 准教授 (50321823)

Co-Investigator(Kenkyū-buntansha) NOGAWA Hiroyuki  千葉大学, 理学研究科, 准教授 (40143250)
NOGAWA Hiroyuki  福島県立医科大学, 医学部, 准教授 (80250190)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords唾液分泌低下 / 放射線療法 / がん化学療法 / がん治療の有害事象 / 唾液腺培養系
Outline of Final Research Achievements

Radiotherapy for head and neck cancers and/or chemotherapy can cause salivary gland dysfunction and subsequent xerostomia, leading to poor quality of life (QOL) in cancer survivors. To understand the molecular mechanism of the salivary gland dysfunction and develop a preventive care, we are trying to establish an ex vivo salivary gland culture system. To develop the culture system, we tested the effects of growth factors on cultured epithelia of mouse embryonic submandibular glands. This study showed that it is possible to establish the ex vivo salivary gland culture system which can maintain c-Kit+ cells by adding NRG1 + FGF1 and differentiate into AQP5+ cells by removing FGF1 whenever necessary.

Free Research Field

基礎看護学、細胞生物学

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Published: 2017-05-10  

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