2015 Fiscal Year Final Research Report
Analysis of lipotoxicity induced by fatty acids
| Project/Area Number |
25504005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
SHIMOMURA Yoshiharu 名古屋大学, 大学院生命農学研究科, 教授 (30162738)
KADOTA Yoshihiro 名古屋大学, 大学院生命農学研究科, 研究員 (10724776)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脂肪酸 |
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| Outline of Final Research Achievements |
Free fatty acid (FFA) has been reported to induce cell death (lipotoxicity), but the effect depends on the carbon chain length and number of double bonds. In this study, we found that the lipotoxicity and influx rate of FFA were changed by their combinations. We also identified one of the anti-cancer FFA combination, and revealed the effect of FFA on amino acid catabolism.
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| Free Research Field |
栄養生化学
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