2015 Fiscal Year Final Research Report
Analyses of the microRNAs regulating the expression of type 2 diabetes mellitus-susceptibility genes
| Project/Area Number |
25504007
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Integrated Nutrition Science
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOSHINAO GODA 静岡県立大学, 食品栄養科学部, 教授 (70195923)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 生活習慣病 / 糖尿病 / microRNA |
|---|
| Outline of Final Research Achievements |
We found the 3’UTR SNP (rs2229295) in the HNF1B gene was associated with the susceptibility of T2DM. In addition, luciferase reporter assays indicate that the substitution of C>A due to SNP (rs2229295) induces the binding of hsa-miR-214-5p/hsa-miR-550a-5p to the 3′UTR of the HNF1B gene. There is a possibility that the binding of such miRNAs regulates the expression of the HNF1B gene and susceptibility of T2DM.
|
| Free Research Field |
統合栄養科学
|
