2016 Fiscal Year Final Research Report
Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food
| Project/Area Number |
25504014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Hashimoto Ryota 順天堂大学, 医学部, 助教 (60433786)
Kakigi Ryo 順天堂大学, 医学部, 助教 (70614931)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 血管内皮細胞 / 一酸化窒素 / 血管弛緩反応 / フコイダン / 一酸化窒素合成酵素 |
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| Outline of Final Research Achievements |
Fucoidan is a natural sulfated polysaccharide obtained from brown marine algae composed predominantly of sulfated fucose. The objectives of the present study are to investigate the effects of fucoidan on cardiovascular system and to explore the mechanism(s) of action, leading to the clarification of scientific basis of its usefulness as a functional food. The present study showed that fucoidan caused vascular relaxation through endothelium-dependent, nitric oxide (NO)-mediated mechanism in isolated rat aorta and this relaxation seemed to be caused through an activation of endothelial nitric oxide synthase (eNOS).
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| Free Research Field |
生理学
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