2016 Fiscal Year Final Research Report
A study of hydrogen sulfide donor to prevent alzheimer's disease
| Project/Area Number |
25504015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nihon University |
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Principal Investigator |
HOSONO Takashi 日本大学, 生物資源科学部, 講師 (80445741)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | アルツハイマー病 / 硫化水素 / ガーリック / 神経細胞 / アミロイドβ |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the protective effect of food factor on Alzheimer's disease. We found that diallyl trisulfide (DATS) derived from garlic is hydrogen sulfide donor compound. Amyloid β induced neuronal cell death in primary neuronal cell cultures and neuronal cell line PC12. DATS and other hydrogen sulfide donor compounds had little effects on neuronal cell death induced by amyloid β. We revealed that DATS has anti-inflammatory activity.
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| Free Research Field |
食品科学、神経科学、細胞生物学
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