Evaluation of vitamin E status using urinary excretion of vitamin E metabolites

2015 Fiscal Year Final Research Report

• Project/Area Number: 25504017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Nagoya University of Arts and Sciences
• Principal Investigator: Ikeda Saiko 名古屋学芸大学, 管理栄養学部, 教授 (80308808)
• Co-Investigator(Kenkyū-buntansha): NOMURA SAKI 名古屋学芸大学, 管理栄養学部, 助手 (90588956)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ビタミンE / トコフェロール

Outline of Final Research Achievements

We examined the effect of tocopherol supplementation on its metabolite (CEHC) excretion. Study 1: Tocopherol intake, serum tocopherol concentration, and urinary excretion of CEHC of healthy young women was measured. Neither gamma-tocopherol intake nor serum gamma-tocopherol concentration was correlated with gamma-CEHC excretion, although gamma-tocopherol intake was correlated with serum gamma-tocopherol concentration.　Study 2: Healthy young people took 100 mg of alpha-tocopherol, 100 mg of gamma-tocopherol, or placebo. The result that increases of serum tocopherol concentration and urinary CEHC excretion, suggested fast catabolism of gamma-tocopherol compared with alpha-tocopherol.　Study 3: Healthy young women took gamma-tocopherol (100 mg/d), or gamma-tocopherol (100 mg/d) with alpha-tocopherol (50 mg/d), for 7 days. Gamma-tocopherol intake lowered serum alpha-tocopherol concentration and enhanced CEHC excretion, suggesting accerelation of alpha-tocopherol catabolism.

Free Research Field

食生活学