2015 Fiscal Year Final Research Report
The role of ghrelin, an appetite-promoting hormone on abnormal feeding behavior in obesity
| Project/Area Number |
25504019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAJIRI Yuji 久留米大学, 医学部, 准教授 (80469361)
NISHI Yoshihiro 久留米大学, 医学部, 講師 (20352122)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
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| Research Collaborator |
HARA Kento
SAKAI Yusuke
OKABE Yuri
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | グレリン / グレリン遺伝子欠損マウス / 高脂肪食 / 摂食リズム / 肥満制御 / ニューロメジン / 末梢時計遺伝子 |
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| Outline of Final Research Achievements |
The present study was undertaken to evaluate the relevance of ghrelin, an appetite-promoting hormone, for the mechanism of eating disorder in high fat diet (HFD)-induced obesity. For this purpose, we investigated roles of ghrelin under energy derangement caused by HFD in animal model, especially its rhythm together with feeding rhythm in the formation of obesity. Furthermore, we evaluated autonomic nervous activity in obese patients in relation to abnormal binge eating behavior often observed in these subjects. In result, diurnal rhythm of ghrelin production was severely shifted by HFD, suggesting its relevance in abnormal feeding behavior characterized by an increase of food intake during light phase. Furthermore, we clarified the participation of peripheral clock genes in the formation of feeding rhythm abnormality. In obese patients, parasympathetic activity was suppressed during night, suggesting a possible contribution to blunted quality of life in these subjects.
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| Free Research Field |
内分泌学・実験動物学
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