2016 Fiscal Year Final Research Report
Analysis of gravity sensor for medaka osteoclast via space experiment
| Project/Area Number |
25514003
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
|
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| Research Institution | Showa University (2016)
Tokyo Institute of Technology (2013-2015) |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 宇宙 / 骨 / メダカ / 破骨細胞 / 重力 |
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| Outline of Final Research Achievements |
Space flight in a reduced gravity environment can have lasting effects on the body. For example, astronauts undergo a significant drop in bone mineral density during space mission, but the molecular mechanisms responsible for such changes in bone density are unclear. To identify the mechanisms, twice unique experiments were performed at international space station by using medaka fish. One was long-term experiment for analysis of bone growth during 2 months, resulting in the decrease of mineral density for pharyngeal teeth bones. Another was short-term experiment for live-imaging of transgenic medaka lines and transcriptome analysis during 8 days, resulting in the increase of the expression levels for 5 genes. Taken together, medaka fish studies give scientists a good starting point to figure out how the process actually occurs.
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| Free Research Field |
骨生物学
|
