Narcolepsy-like state in chronic sleep deprivation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25515005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Bunkyo Gakuin University
• Principal Investigator: Usui Akira 文京学院大学, 保健医療学部, 客員教授 (40203517)
• Co-Investigator(Renkei-kenkyūsha): INOUE Yuichi 公益財団法人神経研究所, 研究部, 研究員 (50213179) ; KAWARA Tokuhiro 文京学院大学, 保健医療学部, 教授 (50234141) ; MASHIYAMA Rieko 文京学院大学, 保健医療学部, 非常勤講師 (10515810)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 過眠 / ナルコレプシー / 情動脱力発作 / HLA-DQB1*06:02 / 睡眠潜時反復検査 / 平均睡眠潜時 / SOREMPs / 平均レム潜時

Outline of Final Research Achievements

The nocturnal sleep time of university students was 5.80 hours on weekdays and 7.69 hours on weekends based on sleep log, and total record time was less than 5 hours in portable electroencephalography on weekdays. In this sleep deprivation state, subjective sleepiness was alleviated when sleep time on weekends was long, but objective sleepiness (multiple sleep latency test; MSLT) fulfilled narcolepsy criteria by 24% of subjects.
For patients of daytime sleepiness, the receiver operating characteristic curve analyses appeared the optimal cutoffs for narcolepsy type 1 (NT1) were mean sleep latency less than or equal to 2.38 minutes, three or more sleep onset REM periods and mean REM latency less than or equal to 3.50 minutes. By logistic regression analysis, NT1 was associated only with the number of DQB1*06:02 alleles, although narcolepsy type 2 was associated with younger age, male sex and a difference in sleep times between weekdays and weekends.

Free Research Field

精神医学、睡眠学、臨床神経生理学