2016 Fiscal Year Final Research Report
Mechanical properties of the collapsible upper airway in obstructive sleep apnea patients
| Project/Area Number |
25515010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
TSUIKI Satoru 公益財団法人神経研究所, 研究部, 研究員 (90376765)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Tatsuya 公益財団法人神経研究所, 研究部, 研究員 (90624833)
KOBAYASHI Mina 公益財団法人神経研究所, 研究部, 研究員 (40596037)
NAKAYAMA Hideaki 東京医科大学, 医学部, 准教授 (30444144)
INOUE Yuichi 公益財団法人神経研究所, 研究部, 研究員 (50213179)
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| Research Collaborator |
ISONO Shiroh
TAKEI Yoichiro
ENO Yukiko
EBATO Arisa
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 睡眠時無呼吸症候群 / 上気道 |
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| Outline of Final Research Achievements |
In individuals with obstructive sleep apnea (OSA), a neuromuscular compensation mechanism is augmented in defense of upper airway patency. We investigated the volume-pressure relationship of the isolated upper airway in 7 OSA patients. The volume-pressure properties were evaluated in terms of elastance of the upper airway (Euaw). A significant correlation was observed between Euaw and the Apnea Hypopnea Index. Accordingly, the upper airway is less collapsible in the more severe OSA patients probably due to the more increased upper airway muscle activity.
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| Free Research Field |
睡眠学
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