Statistical Models for Fractionated Irradiation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25540008
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Hokkaido University
• Principal Investigator: Mizuta Masahiro 北海道大学, 情報基盤センター, 教授 (70174026)
• Co-Investigator(Kenkyū-buntansha): DATE Hiroyuki 北海道大学, 大学院保健科学院, 教授 (10197600)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 線量効果に関する数理モデル / 悪性腫瘍 / 危険臓器 / 制約条件付最適化

Outline of Final Research Achievements

Radiotherapy of solid tumors has been performed with various fractionation regimens. However, mathematical model for the fractionation regimens remains insufficient. We forces on (modified) linear-quadratic models and construct a framework for evaluation of fractionation regimens based on the models.
It was found that the optimization of fractionation scheme incorporating the dose volume histogram is possible by employing appropriate cell surviving models. It is possible to optimize the number of fractions and dose per fraction based on the physical dose distribution considering the effects on tumor and organ at risks (OARs) around the tumor. This method may stipulate a new guideline to optimize the fractionation regimen for physics-guided fractionation.

Free Research Field

統計科学