Development of the intestinal function imitated model in vitro system for searches of the newly allergic induction/exacerbation compounds

2014 Fiscal Year Final Research Report

• Project/Area Number: 25550040
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Setsunan University
• Principal Investigator: OHTA Souichi 摂南大学, 薬学部, 教授 (10213729)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 食物アレルギー / 疾病予防 / 環境汚染物質 / 恒常性攪乱物質 / ダイオキシン / 簡易迅速試験法

Outline of Final Research Achievements

It is suggested that the immune diseases such as allergies causes it with the disruption of epithelial cell barrier. In this study, we performed the basic data for development of the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time. It was observed that various environmental pollutants were decreased barrier function, and disrupted the immune response. This　observation suggested the possibility to develop the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time.

Free Research Field

環境保健学