Recommended practical intake level of cancer preventive isothiocyanate in cruciferous vegetables with reflecting the bioavailability

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560039
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kyoto Prefectural University
• Principal Investigator: NAKAMURA YASUSHI 京都府立大学, 生命環境科学研究科, 教授 (90285247)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ダイコン / MTBITC / 生体内利用能 / がん予防 / 京野菜

Outline of Final Research Achievements

Our goal is to establish a recommended practical intake level of cancer preventive isothiocyanate (4-methylthio-3-butenyl isothiocyanate) in daikon with reflecting the bioavailability in human body. The MTBITC bioavailability varied among human volunteers, and therefore the MTBITC cancer preventive effect depends on the individual even in the same MTBITC administration level. The difference does not depend on gender, age, height, and weight in individual. The bioavailability was observed upper limit, and the cancer preventive effect might be expected under the limit of bioavailability accordingly. Since variation factor of the MTBITC bioavailability was found in seasons changed over time, it might be useful to estimate the bioavailability in each season, when establish the recommended practical intake level of daikon for cancer preventive effect.

Free Research Field

食品機能学