Does procyanidin show an incretin effect?

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560049
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kobe University
• Principal Investigator: ASHDIA Hitoshi 神戸大学, (連合)農学研究科(研究院), 教授 (90201889)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: プロシアニジン / インクレチン / 保健機能食品

Outline of Final Research Achievements

Procyanidins, in particular cinnamtannin A2 possessed secretion of incretin hormone, GLP-1, and subsequently increased secretion of insulin from beta-cells. This effect led to improve postprandial hyperglycemia by promoting GLUT4 translocation to the plasma membrane. As the molecular mechanism, cinnamtannin A2 activated both insulin- and AMPK-signaling pathways. Other Procyanidins also increased part of insulin-signaling pathway in addition to the AMPK-signaling pathway. From these results, procyanidins are effective food factors for prevention of hyperglycemia.

Free Research Field

食品機能学