Diets may contribute to the improved cellular function via the modulation of AKT signaling

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560050
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Nara Women's University
• Principal Investigator: MATSUDA Satoru 奈良女子大学, 研究院生活環境科学系, 教授 (50242110)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 細胞内シグナル伝達 / 遺伝子発現 / 生活習慣病

Outline of Final Research Achievements

Reactive oxygen species (ROS) play an important role in the inflammation processes as well as in transduction of signals from receptors for several cytokines such as tumor necrosis factor α (TNFα). ROS activate nuclear factor kB (NF-kB) via IkB kinase (IKK) through PI3K/AKT/PTEN pathway. Regulation of the PI3K/AKT pathways may also constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways modulate cell proliferation, migration, and plasticity. The PI3K/AKT/PTEN pathway has been shown to play a pivotal role in several disease protections. Although PTEN has been discovered as a tumor suppressor, PTEN is also involved in several other diseases, including diabetes and Alzheimer's disease. Dietary fish oil rich in polyunsaturated fatty acids may induce the PTEN expression by activation of peroxisome proliferator-activated receptor.

Free Research Field

食品機能分子生物学