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2014 Fiscal Year Final Research Report

Molecular basis of immunomodulatory effect of dietary alpha-glucans

Research Project

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Project/Area Number 25560051
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionHiroshima University

Principal Investigator

KAWAMOTO Seiji  広島大学, 先端物質科学研究科, 教授 (90294537)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsα-グルカン
Outline of Final Research Achievements

Objective of this study was to test the hypothesis that rice-derived alpha-glucan plays a role in health-promotion of Japanese people through modulation of host-defense system.
Oral feeding with rice-derived starch significantly suppressed the development of nasal symptoms in a murine model of allergic rhinitis without affecting adaptive immunity. The anti-inflammatory effect was more potent in uruchi-rice than in mochi-rice, suggesting that a major anti-allergic alpha-glucan unit was amylose. I also found a possibility that one could modulate such anti-allergic potency by regulation of rice starch consumptions.

Free Research Field

食品機能学

URL: 

Published: 2016-06-03  

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