Circulating-miRNA in peripheral blood in metabolic state of between distant organs

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560055
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Nagasaki University
• Principal Investigator: MORI Ryoichi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30509310)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: miRNA / 代謝 / 高脂肪 / 寿命

Outline of Final Research Achievements

Circulating miRNAs (c-miRNAs) is involved in metabolic state of between distant organs, however its functions have not been elucidated. In this study, to clarify functions of intercellular and extracellular inflammation-related miRNA in vivo, I have recently generated miRNA knockout (KO) mice and while they are grossly normal through embryogenesis, they are very vulnerable to live at early postnatal stages. Those individuals that make it through the neonatal period thrive and are fertile as adults and display no gross abnormalities. these results indicated that miRNA is contributed to homeostatic mechanism and other biological phenomenon such as inflammation and tissue repair.

Free Research Field

実験病理学、老化学、代謝学、免疫学