Elucidation of molecular mechanisms for diabetes induced by soft diet

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560056
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: University of Miyazaki
• Principal Investigator: Date Yukari 宮崎大学, 理事 (70381100)
• Co-Investigator(Renkei-kenkyūsha): Akieda Sayaka 宮崎大学, フロンティア科学実験総合センター, 助教 (20549076) ; Senba Kazuyo 別府大学, 食物栄養科学部, 准教授 (30381031) ; Miyazato Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183) ; kangawa Kenji 独立行政法人国立循環器病研究センター, 生化学部, 所長 (00112417)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 軟食 / 糖尿病 / インスリン抵抗性 / 脂肪肝 / 膵ラ氏島過形成

Outline of Final Research Achievements

In this study, we found that rats fed soft diet on 3-h restricted feeding show glucose tolerance, insulin resistance, and lipid accumulation in the liver. These rats also demonstrated impairment of insulin signal transduction in the liver and increase in the number of islets compared with rats fed standard chow. We showed that lipid accumulation factors induced by hyperglycemia and hyper insulinemia also increase in rats fed soft diet. Taken together, it was thought that rats fed soft diet on 3-h restricted feeding could be a novel of type II diabetes without significant obesity like Japanese and Asian people.

Free Research Field

内分泌学・代謝学